Ian Bell has been ruled out of the fifth and final Royal London Series match against India at Headingley because of a broken toe.
England were initially planning to assess Bell's injury in practice on Thursday, but have decided already he will not recover in time to play the following day.
They will not, however, be calling up a replacement.
Bell was hit on the left big toe while facing throw-downs in practice drills before Tuesday's nine-wicket defeat at Edgbaston, where his number three position was instead filled by Gary Ballance.
An England and Wales Cricket Board press release explained on Wednesday afternoon that Bell has played his last international match of the summer.
It read: "England and Warwickshire batsman Ian Bell has been ruled out of the final Royal London ODI against India on Friday with a small fracture to his left big toe, sustained yesterday before the ODI at Edgbaston."
"Bell will not be replaced in the squad for the remaining match."
England's defeat in Birmingham means they have lost the series, and will be trying to avoid a 4-0 whitewash in Leeds.